منابع مشابه
Pentoxifylline for intermittent claudication.
BACKGROUND Intermittent claudication (IC) is a symptom of peripheral arterial disease (PAD) and is associated with high morbidity and mortality. Pentoxifylline, one of many drugs used to treat IC, acts by decreasing blood viscosity, improving erythrocyte flexibility and promoting microcirculatory flow and tissue oxygen concentration. Many studies have evaluated the efficacy of pentoxifylline in...
متن کاملPentoxifylline for intermittent claudication. A critical review.
Pentoxifylline was first introduced in Germany twenty years ago. Today it is the best researched oral drug for intermittent claudication. A total of seventeen placebo-controlled trials could be retrieved from the world literature. The majority of these studies show that pentoxifylline will prolong the walking distance in a statistically significant way. Even though these trials are conducted wi...
متن کاملDifferential effects of cilostazol and pentoxifylline on vascular endothelial growth factor in patients with intermittent claudication.
Cilostazol is a new phosphodiesterase inhibitor with anti-platelet and vasodilatory properties. Cilostazol and pentoxifylline are the only two drugs that have been approved for the treatment of patients with intermittent claudication. However, the mechanisms by which exercise tolerance is improved remain unclear. Vascular endothelial growth factor (VEGF) is a potent endothelial mitogen that res...
متن کاملTreatment of intermittent claudication with physical training, smoking cessation, pentoxifylline, or nafronyl: a meta-analysis.
BACKGROUND There is no consensus on the efficacy of physical training, smoking cessation, and pharmacological therapy (pentoxifylline or nafronyl oxalate) in the treatment of patients with intermittent claudication at Fontaine stage II of disease. METHODS A MEDLINE and manual search was used to identify relevant publications. Uncontrolled or retrospective studies, double reports, and trials w...
متن کاملManagement of intermittent claudication with pentoxifylline: meta-analysis of randomized controlled trials.
OBJECTIVE To evaluate the efficacy of pentoxifylline therapy in improving the walking capacity of patients with moderate intermittent claudication. DATA SOURCES A search of MEDLINE for trials published between 1976 and 1994 inclusive, and a bibliographic review of all articles retrieved. STUDY SELECTION Randomized, placebo-controlled, double-blind clinical trials were selected that evaluate...
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ژورنال
عنوان ژورنال: Journal of Vascular Surgery
سال: 1988
ISSN: 0741-5214
DOI: 10.1016/0741-5214(88)90320-5